Vinod NikhraHindu Rao Hospital & NDMC Medical College · Department of Medicine
Vinod Nikhra
1.87
·
M.D., PGCHM, ICCN, FIMSA, Fellow Royal Society of Medicine
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Introduction
Dr Vinod Nikhra is Consultant and Faculty at NDMC Medical College and Hindu Rao Hospital, a multispecialty in New Delhi. He is a healthcare administrator, academician and clinician. He is an M.D. in Internal Medicine, and qualified and trained in nephrology, endocrinology, and cardiology, and hospital management. He is a Fellow by International Medical Sciences Academy and the Royal Society of Medicine. He has been Editor of “Madhya: the midage”, the official Journal of Association for Health in Middle Aged. He is a Editorial Board Member, the Open Access Journal of Gerontology and Geriatric Medicine and on Reviewer panel of several medical journals. He is a published Author of four books, which include his widely acclaimed books, ‘Aging slowly, Living longer' and 'The Anti-obesity Guide.'
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Projects (8)
To understand that how these two factors may be related
Research
Research items (50)
NAFLD-Prevalence and Associations: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent metabolic disorder having as key feature, the insulin resistance (IR), accompanied with impaired insulin sensitivity (IS) in liver and other organs including muscles and adipose tissues. Further, the incidence of NAFLD is high in conditions associated...
BIORHYTHMS, REDUNDANCY AND RESERVE: The dynamic equilibrium in the interactions of biorhythms with the rhythms of the surrounding ecosystem forms the basis of life. The biorhythms can be categorized by their relationship to 24-h day cycle as circadian, ultradian and infradian. In addition, there are other rhythmic patterns generated outside the CNS...
Altered insulin sensitivity and insulin resistance: Insulin is an anabolic hormone and regulates glucose homeostasis and other metabolic processes in various organs. At the cellular level, the insulin triggers signalling cascades that regulate cell metabolism, cell proliferation and cell survival. With aging, there occurs an impairment of glucose-s...
Aging process and humoral alterations The aging is a temporal process involving a general decline in various physiological functions and a reduced capacity to maintain efficient homeostasis and reparative mechanisms, resulting in loss of function and senescence. In addition, the aging is associated with significant changes in the regulation of horm...
Microbial Alterations and Dysbiosis: The composition and diversity of gut microbiota is an indicator of health and various groups of commensal bacteria provide health advantages as they enhance metabolism, the immune system, cancer resistance, endocrine signaling and brain function. In general, the gut microbiome remains relatively resilient over t...
CANNABIS USE AND AVAILABILITY: The Cannabis derivatives have been used for recreational and medicinal purposes since ancient times. Because of the additive potential of cannabis products, their sale, possession and use are variously regulated in different countries throughout the world. Still as a psychoactive drug, cannabis continues to find exten...
THE NEW DIMENSION IN CARDIO-METABOLIC HEALTH: Cardio-metabolic disorders (CMDs) encompass various disorders like metabolic syndrome, obesity, diabetes and cardiovascular disease (CVD) including atherosclerosis, hypertension, coronary artery diseases, cerebrovascular disease and heart failure. CMD occur due to insulin resistance (IR), inflammation,...
THE NEW DIMENSION IN CV HEALTH: Cardiovascular disease (CVD) encompasses various disorders including atherosclerosis, hypertension, coronary artery diseases, cerebrovascular disease and heart failure. Various predisposing factors including genetic ones are involved. The novel factors such as nutrition, and gut microbial dysbiosis have also been imp...
METABOLIC DISEASE AND AGING: There is increasing evidence that metabolic disequilibrium and disorders influence the aging process and survival including the quality of life (QOL). The adipose tissue mediates various age-associated metabolic disorders such as insulin resistance (IR), metabolic syndrome (MetS), dyslipidemia and type 2 diabetes mellit...
The Health Preservation and Longevity: The prolongation of life span achieved in recent decades is triumph of modern medicine. The lead challenge now is to promote healthy lifespan along with reducing incidence and severity of chronic and degenerative diseases, and the morbid frailty associated with later years. The host-microbiota interactions can...
MICROBIAL ALTERATIONS AND DYSBIOSIS: The composition and diversity of gut microbiota is an indicator of health and various groups of commensal bacteria provide health advantages as they enhance metabolism, the immune system, cancer resistance, endocrine signaling and brain function. In general, the gut microbiome remains relatively resilient over t...
ABSTRACT
GENESIS OF MICROBIAL DYSBIOSIS: The human intestinal microbiota performs several vital functions, acting in tandem with the host's defence and immune system. Maintenance of microbiota is vital for preservation of health and imbalances in the microbiome shift the microbiome-host relationship from symbiotic to pathogenic. Gut microbial dysbi...
ABSTRACT
ESTABLISHMENT OF INFANT MICROBIOME - FIRST 100 DAYS: The human intestinal bacterial colonization begins when the fetus is in the lower uterus. Though, the actual infant microbiota is established after birth and passes through various transition phases. The first transition occurring soon after birth, during lactation, results in dominance...
THE HEALTH PRESERVATION AND LONGEVITY: The prolongation of life span achieved in recent decades is triumph of modern medicine. The lead challenge now is to promote healthy lifespan along with reducing incidence and severity of chronic and degenerative diseases, and the morbid frailty associated with later years. The host-microbiota interactions can...
ABSTRACT
CARDIOVASCULAR HEALTH AND NUTRACEUTICALS: CVD is common, morbid and responsible for about 17.3 million deaths annually worldwide. The modifiable risk factors include obesity, hypertension, hyperlipidaemia, T2DM, MetS and lifestyle risk factors such as smoking, physical inactivity and dietary factors. Foods and nutrients play a vital role i...
Introduction - Obese-obese World: The obesity and metabolic syndrome (MetS) are a global epidemic of such magnitude that today’s health scenario can be summed up as the ‘Obese-obese World’*. Obesity and MetS deteriorate quality of life and alter course of various chronic diseases, and on their own, are risk factors for diabetes, hypertension, cardi...
CR - THE CONCEPT: The energy needs are determined by the body composition, especially the fat-free lean mass and level of physical activity, and there is a change in nutritional needs during the middle age and later. The diet-gene interaction is a major determinant of health and illness, and the amount and type of food ingestion and caloric intake,...
Nutrition and Cardiovascular Health: CVD is common, morbid and responsible for about 17.3 million deaths annually worldwide. The modifiable risk factors include obesity, hypertension, hyperlipidaemia, T2DM, MetS and lifestyle risk factors such as smoking, physical inactivity and dietary factors. Foods and nutrients play a vital role in functioning...
Introduction: ‘The Obese-Obese World’- The obesity and metabolic syndrome (MetS) are a global epidemic of such magnitude that the
today’s health scenario can be summed up as the ‘Obese-obese World’*. Obesity and MetS deteriorate quality of life and alter course of various
chronic diseases, and on their own, are risk factors for diabetes, hypertensi...
Metabolic syndrome (MetS) and obesity with its fallouts including increased oxidative stress, altered glucose, fat and protein metabolism, and altered skeletal muscle mitochondrial function. Redox balance and thioredoxin system: The cellular redox balance is regulated by activity of several antioxidant systems including thioredoxin (TXN) system. Th...
OVERNUTRITION AND ADIPOSITY: Overnutrition contributes to chronic energy surplus leading to adiposity, insulin resistance (IR), metabolic syndrome (MetS) and obesity with its fallouts including increased oxidative stress, altered glucose, fat and protein metabolism, and altered skeletal muscle mitochondrial function. REDOX BALANCE AND THIOREDOXIN S...
CARDIOVASCULAR AGING: MECHANISMS AND PATHWAYS: The heart is made up of millions of myocardial cells that contract and relax to pump blood adequately to various body organs. In turn, it is itself dependent for oxygen and nutrients on vascular supply. There goes on the ongoing damage to the heart and vasculature with aging. Various adaptive and compe...
Longevity research.
Attempts for Life Extension.
THE LIVING AND AGING: The phenomenon of aging is universal in the kingdom of living. With time, all living beings age. There have been immense developments in the scientific understanding of biology of aging and the changes that take place with aging at cellular and molecular levels. At the same time, the progress in healthcare and technology has m...
The complex adipose organ It has highly plasticproperties to reprogram its genes and transdifferentiate reversibly into cells with different structure and functions.The adipose organ plays important role in health and disease states including obesity and MetS and fulfils several crucial survival needs like thermogenesis, storage of energy and fuel...
CR - THE CONCEPT: The energy needs are determined by the body composition, especially the fat free lean mass and level of physical activity, and there is a change in nutritional needs during the middle age and later. The diet-gene interaction is a major determinant of health and illness, and the amount and type of food ingestion and caloric intake,...
PHYSIOLOGY OF APPETITE REGULATION: Appetite functions to ensure sufficient food intake to provide energy for maintaining physiological and metabolic needs. The appetite, in turn, is regulated by a complex process and an intricate interplay of neural and hormonal mechanisms including several brain areas and their projections, various hormones, and g...
OVERVIEW - DIABETES AND CEREBRAL METABOLISM: Diabetes mellitus (DM) per se adversely alters cerebral metabolism, promotes cerebral atrophy and accelerate brain aging, and affects cognitive function. There is a consensus now that the cognitive decline should be listed as one of the major complications of diabetes. The insulin receptors are widely ex...
SURGING PANDEMICITY OF T2DM: The time-old and conventional wisdom holds that T2DM is a metabolic disease characterized by hyperglycemia due to a deficient action of insulin and that diabetic complications result due to high circulating glucose levels and glycation products. But, the characterization of T2DM with hyperglycemia is an overt simplifica...
The aging and underlying pathophysiological alterations are the gradual but heterogeneous. Simultaneously, there are declines of physiological functions, often accompanied by cognitive decline. These alterations are orchestrated through various molecular mechanisms, which complexly interact to Abstract Overview-Neurohormonal Aging: The human aging...
ANOREXIA OF AGING AND
UNDERNUTRITION
There occurs a variable decrease in appetite in about 15 to 30% of older adults. This decline in desire to eat in older adults was described as the ‘anorexia of ageing’ by John Morley and Silver in 19881. The appetite deteriorates with increasing age, being higher in women, hospitalized patients, old age home r...
METABOLIC HOMEOSTASIS AND AGING: There is a close relationship between homeostasis and metabolism. The inability to maintain homeostasis leads homeostatic imbalance, resulting in various metabolic disorders and disease states including diabetes. Aging is an important risk factor for metabolic disorders including obesity, impaired glucose tolerance,...
The heart is made up of millions of myocardial cells that contract and relax to pump blood adequately to various body organs. In turn, it is itself dependent on oxygen and nutrients on vascular supply. All adaptive and compensatory measures including lifestyle interventions and related treatment modalities contributing directly or indirectly to the...
OVERVIEW – NEUROCOGNITIVE AGING: Among all body organs, the aging of human brain is most incapacitating with its fallouts on quality of life, general health and psychosocial implications. There are progressive aging changes in the brain with increasing chronological age. However, at the individual level rate and types of changes are variable. The a...
Age is the most important determinant of cardiovascular (CV) health. There occurs an exponential rise in both the CV risk and the incidence of CV events in older adults parallel with the advancing age. The aging process and its impact, in turn, depend on many factors, from individual genetic constitution to his or her patterns of living which inclu...
Medical Therapy of Heart Failure:
Harnessing the Recent Research and Concepts
ABSTRACT
EPIDEMIOLOGY OF HEART FAILURE (HF): The HF is a complex clinical syndrome complex carrying an increased morbidity and potential loss of work days, hospitalization and substantial cost of treatment. Furthermore, its clinical course is gradually progressive, aff...
The cardio-vascular diseases (CVDs) are highly prevalent in the developed and as well as developing societies. There occurs an exponential rise in both the cardio-vascular (CV) risk and the incidence of CV events in older adults parallel with the advancing age. Also, age is the most important determinant of cardiovascular (CV) health on individual...
The fact: Obesity is a chronic health-threatening disease and the potential of pharmacotherapy for obesity is enormous. Though incidence of obesity is high, only a small percentage of patients are treated with pharmacotherapy. The limiting factors are, firstly, the lack of long-term data on effect of medications on obesity-related morbidity and mor...
The inhalable insulin was available from September 2006 to October 2007 in the United States and some
European countries. It was a novel method of delivering insulin for treatment of diabetes and raised
many hopes for millions of diabetic patients to be able to walk away from the daily painful chore of
injecting insulin. But, then during October 20...